Transforming Cancer Therapeutics

Key Features

UK registered businesses can apply for a share of up to £10 million to develop next generation immunotherapies for cancer or life-changing treatments for paediatric cancers.

Programme:     Innovate UK

Award:     Share of up to £10 million

Opens: 15th Nov 2023

Closes: 24th Jan 2024

! This scheme is now closed

Overview

Innovate UK, part of UK Research and Innovation, will invest up to £10 million in innovation projects to advance next-generation immunotherapies for cancer or life-changing treatment options for childhood cancers.

Your project can focus on one or more of the following:

  • next generation immunotherapies and immunomodulatory drugs
  • manipulation of the tumour microenvironment to promote immune responses against solid tumours
  • novel therapeutics that consider the unique characteristics of paediatric or young people’s cancers
  • clinical decision support tools to optimise treatment selection and therapeutic dosing for children and young people

This list is not intended to be exhaustive.

In applying to this competition, you are entering into a competitive process.

Scope

The aim of this competition is to support innovation projects that focus on advancing next-generation immunotherapies for cancer or life-changing treatment options for childhood cancers.

Innovate UK will only support innovation projects conducted to the highest standards of animal welfare.

Further information for proposals involving animal testing is available at the UKRI Good Research Hub and NC3R’s animal welfare guidance.

Your project can include:

  • experimental evaluation at laboratory scale
  • use of in vitro and in vivo models to evaluate proof of concept or safety
  • exploration of potential production mechanisms
  • prototyping
  • product development planning
  • intellectual property protection
  • a demonstration of clinical utility and effectiveness
  • a demonstration of safety and efficacy including phase 1 and 2 clinical trials
  • regulatory planning

Specific Themes

Your project can focus on one or more of the following:

  • next generation immunotherapies and immunomodulatory drugs
  • manipulation of the tumour microenvironment to promote immune responses against solid tumours
  • novel therapeutics that consider the unique characteristics of paediatric or young people’s cancers
  • clinical decision support tools to optimise therapeutic dosing for children and young people

This list is not intended to be exhaustive.

Eligibility

Your project must:

  • have total costs between £150,000 and £4 million
  • not exceed a grant request of £2 million
  • have at least 50% of the total project costs shared by the SMEs, if collaborative
  • start by 1 Aug 2024
  • end by 31 July 2026
  • last between 6 and 24 months
  • carry out all of its project work in the UK
  • intend to exploit the results from or in the UK

Projects must always start on the first of the month and this must be stated within your application. Your project start date will be reflected in your grant offer letter if you are successful.

You must only include eligible project costs in your application. If you have requested an overall grant of over £500,000, and your online application is successful at written assessment, you may be invited to attend an interview.

Under current restrictions, this competition will not fund any procurement, commercial, business development or supply chain activity with any Russian or Belarusian entity as lead, partner or subcontractor. This includes any goods or services originating from a Russian or Belarusian source.

Lead organisation

To lead a project or work alone your organisation must be a UK registered micro, small or medium-sized enterprise (SME).

More information on the different types of organisation can be found in our Funding rules.

Academic institutions cannot lead or work alone.

Project team

To collaborate with the lead, your organisation must be one of the following UK registered:

  • business of any size
  • academic institution
  • charity
  • not for profit
  • public sector organisation
  • research and technology organisation (RTO)

Each partner organisation must be invited into the Innovation Funding Service (IFS) by the lead to collaborate on a project. Once partners have accepted the invitation, they will be asked to login or to create an account in IFS. They are responsible for entering their own project costs and completing their Project Impact questions in the application.

Partners must accept terms and conditions (T&Cs) and complete the subsidy question in order for the application to be submitted.

To be an eligible collaboration, the lead and at least one other organisation must apply for funding when entering their costs into the application.

Non-funded partners

Your project can include partners that do not receive any of this competition’s funding, for example non-UK businesses. Their costs will count towards the total project costs.

Subcontractors

Subcontractors are allowed in this competition.

Subcontractors can be from anywhere in the UK and you must select them through your usual procurement process.

You can use subcontractors from overseas but must make the case in your application as to why you could not use suppliers from the UK.

You must provide a detailed rationale, evidence of the potential UK contractors you approached and the reasons why they were unable to work with you. We will not accept a cheaper cost as a sufficient reason to use an overseas subcontractor.

All subcontractor costs must be justified and appropriate to the total project costs.

Extenuating circumstances where overseas work may be allowable include, for example, clinical trial in a specific patient population. The application assessors will be asked to judge whether you have sufficiently made a case for the use of overseas subcontractors.

Number of applications

An SME can only lead on one application but can be included as a collaborator in two further applications.

If an SME is not leading any application, it can collaborate in any number of applications.

A large business, academic institution, research and technology organisation (RTO), charity, not for profit or public sector organisation can collaborate on any number of applications.

You can use a previously submitted application to apply for this competition.

Exclusions

Innovate UK are not funding projects that are:

  • therapeutic approaches for adult cancers that do not support the development of immuno-oncology
  • cancer diagnostics that are not a companion diagnostic for a specific immunotherapeutic or paediatric oncology approach

Innovate UK cannot fund projects that are:

  • dependent on export performance, for example giving a subsidy to a baker on the condition that it exports a certain quantity of bread to another country
  • dependent on domestic inputs usage, for example giving a subsidy to a baker on the condition that it uses 50% UK flour in their product

Funding Costs

Up to £10 million has been allocated to fund innovation projects in this competition. Funding will be in the form of a grant. You must not claim more than £2 million in grant against your total project costs. A minimum of 50% of your total eligible project costs must be incurred by SMEs, if collaborative.

If the majority of your organisation’s work on the project is commercial or economic, your funding request must not exceed the limits below. These limits apply even if your organisation normally acts non-economically but for the purpose of this project will be undertaking commercial or economic activity.

For industrial research projects, you could get funding for your eligible project costs of:

  • up to 70% if you are a micro or small organisation
  • up to 60% if you are a medium sized organisation
  • up to 50% if you are a large organisation

For experimental development projects which are nearer to market, you could get funding for your eligible project costs of:

  • up to 45% if you are a micro or small organisation
  • up to 35% if you are a medium sized organisation
  • up to 25% if you are a large organisation

Research participation

The research organisations undertaking non-economic activity as part of the project can share up to 50% of the total eligible project costs. If your consortium contains more than one research organisation undertaking non-economic activity, this maximum is shared between them. Of that 50% you could get funding for your eligible project costs of up to:

  • 80% of full economic costs (FEC) if you are a Je-S registered institution such as an academic
  • 100% of your project costs if you are an RTO, charity, not for profit organisation, public sector organisation or research organisation

Interested in applying for this competition?

Book an appointment to speak to one of our advisors to discuss your eligibility to apply for this Grant Funding opportunity.